Catalytic Zinc Complexes for Phosphate Diester Hydrolysis
نویسندگان
چکیده
منابع مشابه
Catalytic Zinc Complexes for Phosphate Diester Hydrolysis**
Creating efficient artificial catalysts that can compete with biocatalysis has been an enduring challenge which has yet to be met. Reported herein is the synthesis and characterization of a series of zinc complexes designed to catalyze the hydrolysis of phosphate diesters. By introducing a hydrated aldehyde into the ligand we achieve turnover for DNA-like substrates which, combined with ligand ...
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Metal-ion complexes are the most effective artificial catalysts capable of cleaving phosphate diesters under mild aqueous conditions. A central strategy for making these complexes highly reactive has been to use ligand-based alcohols that are coordinated to the ion, providing an ionised nucleophile under neutral conditions but at the expense of deactivating it. We have created a highly reactive...
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One of the greatest challenges in biotechnology and in biochemistry is the ability to design efficient enzymes. In fact, such an ability would be one of the most convincing manifestations of a full understanding of the origin of enzyme catalysis. Despite some progress on this front, most of the advances have been made by placing the reacting fragments in the proper places rather than by optimiz...
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The kinetics of cyclization of 2-hydroxypropyl p-nitrophenyl phosphate (1) promoted by two mononuclear Zn(II) catalytic complexes of bis(2-pyridylmethyl)benzylamine (4) and bis(2-methyl 6-pyridylmethyl)benzylamine (5) in methanol were studied under (s)(s)pH-controlled conditions (where (s)(s)pH refers to [H(+)] activity in methanol). Potentiometric titrations of the ligands in the absence and p...
متن کاملMultiple functional group cooperation in phosphate diester cleavage promoted by Zn(II) complexes.
Zn(II) complexes bearing multiple auxiliary organic groups greatly accelerate the cleavage of a phosphate diester.
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ژورنال
عنوان ژورنال: Angewandte Chemie International Edition
سال: 2014
ISSN: 1433-7851
DOI: 10.1002/anie.201400335